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KMID : 0882419930450020194
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Korean Journal of Medicine
1993 Volume.45 No. 2 p.194 ~ p.199
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Serum Pepsinogen I Levels in Duodenal Ulcer
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차수강
김태호/이준성/김재준/김용태/윤용범/송인성/최규완/김정룡
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Abstract
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ackground : Peptic ulcer is a heterogenous disease which has genetic or acquired factors in the development of the disease. Serum pepsinogen I (PG I) was reported as a marker of the genetic factors. But it is less reported about the relations
between
serum PG I and acquired factors in the development of the disease. The aim of this study was to evaluate serum PG I levels as the genetic or acquired factors in the development of duodenal ulcer.
Method : Fasting serum PG I level were tested in 85 patients with duodenal ulcer, 64 their
family members, and 52 normal controls.
Results :
1) Serum PG I levels in duodenal ulcer patients (104±44 ng/ml) and their family members
(74±29 ng/ml) were significantly higher than that of the control subjects (57±24
ng/ml)(p<0.05). 2) The PG I levels of the family in their family members (78±30ng/ml) who
had duodenal ulcer patient with elevated PG I levels in their family were somewhat
higher than that of the family members (67±19 ng/ml) who had the duodenal ulcer
patients with normal PG I levels, but the difference did not acquire statistical significance
(p<0.05). 3) The mean serum PG I level of smoker (111±47 ng/ml) was higher than that of
non-smoker (84±35 ng/ml). 4) The mean serum PG I levels did not change in duodenal
ulcer patients even after the treatment with H2-receptor blocker.
Conclusion : These results suggested that serum PG I levels may be useful as a genetic
marker in duodenalulcer disease, but might be affected by acquired risk factor like smoking
as well.
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KEYWORD
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